Boston’s Payton Pritchard takes a 3-pointer over Portland’s Anfernee Simons during the second half of Wednesday night’s game at Boston. Charles Krupa/Associated Press

BOSTON — Payton Pritchard scored a career-high 43 points and knocked down a career-best 10 3-pointers to lead the short-handed Boston Celtics past the Portland Trail Blazers 128-118 on Wednesday night.

Derrick White added career highs with 41 points and nine 3s to lead Boston to its eighth victory in 10 games, making Pritchard and White the first Celtic duo to score 40 or more points in the same game and the first duo in NBA history with nine or more 3-pointers each in a game.

With starters Jayson Tatum (shoulder), Jrue Holiday (finger) and Kristaps Porzingis (illness) sitting out, Pritchard picked up the scoring load for a Celtics team that made 23 3-pointers.

The game remained tight throughout the first half, featuring five ties and 15 lead changes. But Boston outscored the Blazers 36-27 in the third quarter.

Anfernee Simons led Portland with 30 points and Shaedon Sharpe added 25.

It was the sixth game of a seven-game trip for the Blazers, who had won four of their previous five.

TAKEAWAYS

Trail Blazers: Boston made some changes in its defensive coverage that kept Portland from getting to the rim for most of the night. It forced the Blazers to shoot more jumpers and they couldn’t match the Celtics’ output from 3-point range.

Celtics: Another solid win in which a reserve stepped up and made a significant impact. Having that depth adds to Boston’s chances of repeating as NBA champions.

KEY MOMENT

After the Blazers cut what had been a 25-point deficit to 124-116 with 2:35 to play, Boston came up with back-to-back stops and made enough free throws down the stretch to preserve the win.

KEY STAT

Pritchard has connected on five or more 3-pointers in 20 games this season, ranking fourth in the NBA.